Sanin A. V., Narovlyansky A. N., Pronin A. V.,. Deryabin P. G

We studied antiviral activity of Phosprenyl and Gamapren in vitro against highly pathogenic strain of avian influenza H5N1 virus. Inoculation of the virus to the susceptible cell culture led to the cytopathogenic effect development. Preliminary introduction Phosprenyl and Gamapren 1 hour prior to infecting the cells at a dose of 10.0 TCID50, completely inhibited the cytopathogenic activity of the virus. At higher doses of virus (100.0 TCID50) we also observed a significant inhibition of infectious activity of virus: 70% of infected cells survived under the action Phosprenyl, and 90% under the action of Gamapren. With the introduction of the preparations simultaneously with the infection of cells with virus at a dose of 10.0 TCID50 virtually 100% of infected cells survived, while in control cultures death of 100% of the cells occurred. After infection with virus at a dose of 100.0 TCID50 Phosprenyl and Gamapren caused 50% protection of the cells. The antiviral effect of the drugs Phosprenyl and Gamapren may be associated not only with their virulicidal, but with anti-viral activity as well.

Keywords avian influenza, Phosprenyl, Gamapren, antiviral activity.

Voprosy Virusologii->Vol 62, № 4 (2017) ISSN: 0507-4088 (Print), 2411-2097 (Online), ISSN-L 0507-4088